Cell Separation · Cell Separation
3D acoustic vortex-driven, redefining label-free cell separation and sample purification standards. Label-free, automated — gentler, cleaner, and more efficient than traditional methods.
VortexSort uses high-frequency acoustic technology to generate stable 3D vortex flow fields in microchannels, enabling high-precision, contact-free cell manipulation. No centrifugation or labeling required — efficiently removes contaminating particles and optimizes cell sample quality. Compatible with downstream cell sorting, flow cytometry, and single-cell sequencing.
Stable, controllable 3D acoustic vortex fields are generated within the VortexSort microfluidic chip. Target cells are separated and enriched without contact or labels based on acoustic property differences. Acoustic radiation force scales with the cube of particle radius while fluid drag force scales linearly — enabling precise size-selective separation by tuning acoustic power.
Separation purity >95%, target cell recovery >95%
Eliminates cross-contamination and aerosols, safeguarding sample quality and operator safety
Buffer compatible with PBS, sterile water, and cell culture media — no re-purification needed
Two Core Functions:
① Precise target cell isolation — no fluorescent labeling required, continuously separates and enriches specific cells from whole blood.
② Efficient sample quality optimization — no centrifugation needed, easily removes debris, dead cells, and other impurities.
Precise acoustic parameter tuning enables 200 nm–50 μm micro/nano particle separation.
Process up to 3 samples in parallel; continuous multi-cycle purification/concentration at 10–100 μL/min.
Minimum sample requirement as low as microliters.
Acoustofluidic-driven manipulation preserves cell viability and functionality — gentle, contact-free.
Industry Challenge
Plasma exchange is critical for treating severe immune disorders and organ failure. However, conventional centrifugation and membrane filtration cause mechanical cell damage, membrane clogging, poor biocompatibility, and are difficult to miniaturize.
VortexSort Solution
Acoustofluidic technology generates sound-field-induced acoustic streaming vortices, enabling contact-free, low-damage blood cell-plasma separation — label-free, gentle, controllable, and easily miniaturized.
Industry Challenge
Large amounts of cell debris and Matrigel residue from organoid pre-processing severely interfere with downstream sequencing and functional assays. Traditional centrifugation and filtration cause significant damage, low precision, and lack standardization.
VortexSort Solution
Using acoustic vortex contact-free manipulation, VortexSort gently and automatically separates single-cell suspensions from debris with high precision and standardization. Rat lung tissue: cell proportion increased from 31.5% to 78.8%, debris reduced from 68.5% to 21.2%. Rat brain tissue: cell proportion increased from 67.6% to 94.9%, debris reduced from 32.4% to 5.1%.
Remove cell debris, platelets, dead cells, and other impurities
Isolate immune cells from whole blood
Pre-enrich rare cells from whole blood or bone marrow
Separate TILs and tumor cells from dissociated tumor single-cell suspensions
Wash and purify tissue-dissociated cell suspensions
Concentrate cell sample volume
Label-free, gentle, and efficient — VortexSort protects your cell samples at every step
